Complexity in Psychopathology: One Size Does Not Fit All

New York City, NY

Heterogeneity and variability in clinical presentation, cognition, and biological measures are well-known in psychiatry research, but these issues are typically seen as confounds.  This complexity is increasingly standing in the way of further advances and the development of new treatments. In addition, recent debates around DSM-5, RDoC, HiTOP, clinical staging, and other approaches to psychopathology indicate that our best hope for meaningful progress is to examine complexity as a feature in itself. With this background, the 2023 meeting will focus on “Complexity in Psychopathology”. We will explore several avenues of current research to turn complexity into an opportunity to understand better and treat psychopathology. ​The meeting will feature speakers describing applications of complexity principles to the study of the brain and behavior. There will also be opportunities to discuss how brain biology and psychopathology interact and mold one another dynamically and how complexity can help us understand this process.

Planned Keynote Talks: ​

  • “Is personalized psychiatry possible?”​
  • “Making sense of complex nature of psychiatric disorders.”

Featured Panels: ​

  • Data– Understanding and handling sources of variability​
  • Development– Homotypic continuity vs. pluripotent syndromes​
  • Diagnosis– Over-specificity and under-specificity in diagnostic systems​
  • Treatment– Heterogeneity of treatment response: What is it and what can we learn from it?​
  • Biology– What has it been difficult mapping biology onto psychopathology?

Dost Ongur, MD, PhD
William P. and Henry B. Test Professor of Psychiatry, Harvard Medical School
Director, Schizophrenia, and Bipolar Disorder Research Program, Mclean Hospital

Book Hotel Accommodations

Located in Manhattan’s Koreatown, the Marinique Hotel is one of the Historic Hotels of America. The Empire State Building, Macy’s Herald Square, Madison Square Garden, and Penn Station are all within a 5-minute walk. Enjoy their on-site restaurant, stylish rooms, and fitness center.

Conference Schedule

Subject to Change

8:30 am-10:00 am
Welcome Remarks
Dost Öngür, McLean Hospital/Harvard Medical School
KEYNOTE: Making Sense of Complexity in Psychiatric Disorders
with Kenneth Kendler, Stephan Heckers

10:15 am-12:00 pm
Session 1: Data Understanding and Handling Sources of Variability in Observational and
Experimental Studies with Danielle Bassett, Satrajit Ghosh, Damien Fair

12:00 pm-1:00 pm
Lunch Break (on own)

1:00 pm-3:00 pm
Session 2: Development Homotypic Continuity or Pluripotent Syndromes? with Tyrone Cannon, Joan Luby, Lauren Ellman. Discussant – Ian Hickie

3:00 pm-3:30 pm
Break

3:30 pm-5:00 pm
Junior Scientist Roundtable

5:00 pm-6:30 pm
Poster Session 1

8:30 am-9:30 am
KEYNOTE: Is Personalized Medicine Possible?
George Davey-Smith

9:30 am-11:15 am
Session 3: Diagnosis
Over-Specificity and Under-Specificity with Kathleen Merikangas, Sophia Frangou, Lea Davis

11:30 am- 12:00 pm
Oral Poster Presentations

12:00 pm-1:00 pm
Lunch Break (on own)

1:00 pm-3:00 pm
Session 4: Estimating Treatment Effects and Heterogeneity of Treatment Response with Michel Hernan, Stefan Leucht, Elizabeth Stuart

3:00 pm-3:30 pm
Break

3:30 pm-4:00 pm
Open Discussion led by Dost Ongur

4:00 pm-5:00 pm
APPA Annual Business Meeting

5:00 pm-6:30 pm
Poster Session 2

6:30 pm-7:45 pm
President’s Reception (by invitation)

8:30 am-11:30 am
Session 5: Biology Difficulty Mapping From Biology Onto Psychopathology with Christopher Bartley, Lena Palaniyappan, Yasmin Hurd, David Redish, Abigail Greene

11:00 am-12:00 pm
Session 6: Population Complexity with Ana Gomez-Carrillo

12:00 pm-12:30 pm
Honorary Awards Presentation 

CME/CE Information

CME and CE credits will be available for the meeting at an additional charge. Participants at the annual conference include students, mental health scientists, and practitioners. An important APPA function is to provide a forum for high-level professional and social contact between established investigators, younger researchers, interested clinicians, and trainees. Special registration rates are available for students attending the meeting.

Trainee Workshop

Wednesday, March 1, 2023, 12:30pm-6:30pm

This pre-conference Training Workshop is offered each year and is open to undergraduate, graduate and doctoral students. Registration for the Training Workshop is included in the cost of APPA 2023 Annual Meeting registration.

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