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2022 Meeting


11:00 AM – 11:10 AM   Break

11:10 AM – 12:30 PM   SESSION 2: Rhythms and Psychopathology
Dost Ongur, MD, PhD, Harvard Medical School, McLean Hospital, Chair
Kathleen Merikangas, PhD, NIMH, Rhythms and Bipolar Disorder
Fabio Ferrarelli, MD, PhD, University of Pittsburgh, Sleep Oscillatory Abnormalities in Psychosis: From Chronic Schizophrenia (SCZ) to Clinical High-Rish Patients

12:30 PM – 1:15 PM   Break

1:15 PM – 2:45 PM   SESSION 3: Influences of Neurodevelopmental and Environmental Factors on Rhythm
Susan Santangelo, ScD, Maine Center Research Institute, Tufts University School of Medicine, Chair
Shu Buckley, MD, NIMH, Sleep Unique Oscillations, Neurodevelopment and Behavior
Briana Taylor, PhD, Maine Medical Center Research Institute, The Developmental Course of Circadian Rhythms in Typical and Atypical Development
Benicio Frey, MD, PhD, McMaster University, St. Joseph’s Hospital, Biological Rhythms Across Pregnancy and the Postpartum Period: Link with Mood and Anxiety

2:45 PM – 3:00 PM  Break

3:00 PM – 5:00 PM   SESSION 4: Roundtable: Tools and Analytic Methods to Capture Short Term Dynamics and Individualized Profiles
Femke Lamers, PhD, Amsterdam UMC, Chair, Roundtable: Analytic Challenges for Dynamic Data
Joel Swendsen, PhD, National Center for Scientific Research (CNRS), France, The Risks and Benefits of Mobile Technologies in the Mental Health Field
John Torous, MD, Beth Israel Deaconess Medical Center, Harvard Medical School, Update on Mobile Apps for Monitoring and Interventions in Mental Disorders
Randy Auerbach, PhD, Columbia University, Real-Time Monitoring to Improve the Prediction of Suicide Among Adolescents
Patrick Shrout, PhD, New York University, Roundtable: Analytic Challenges for Dynamic Data
Andrew Leroux, PhD, University of Colorado, Roundtable: Analytic Challenges for Dynamic Data
Celine Vetter, PhD, XIMES GmbH, Roundtable: Analytic Challenges for Dynamic Data
Vadim Zipunnikov, PhD, Johns Hopkins Bloomberg School of Public Health, Roundtable: Analytic Challenges for Dynamic Data

5:00 PM – 5:30 PM   Break

5:30 PM – 5:45 PM  Oral Presentations

5:45 PM – 7:00 PM   Poster Session

5:45 PM – 7:00 PM   Gather.Town Reception

Friday, March 4, 2022

8:00 AM – 9:00 AM   Breakfast Roundtable: Junior Investigator and Trainees

9:00 AM – 11:00 AM   SESSION 5: Building the Time Dimension into Treatment and Prevention
James Potash, MD, PhD, Johns Hopkins, Chair
Reut Gruber, PhD, McGill University, Community and School Interventions to Promote Adolescent Sleep Health
Tina Goldstein, PhD, University of Pittsburgh Medical Center, Western Psychiatric Hospital, Interpersonal and Social Rhythm Therapy (IPSRT) for Adolescents At-Risk for Bipolar Disorder
David Smith, PhD, Cincinnati Children’s Hospital Medical Center, Time of Day Influence on Pharmacologic Treatments
Allan Young, PhD, King’s College London, Discussant
Ian Hickie, MD, The University of Sydney, Discussant

11:15 AM – 12:00 PM   Business Meeting

12:00 PM – 12:15 PM   Break

12:15 PM – 3:45 PM   SESSION 6: Multidisciplinary Perspective on Incorporating Timing and Course into Personalized Mental Health
Kathleen Merikangas, PhD, NIMH, Chair
Ezra Susser, MD, DrPH, Columbia University, “Precision Medicine” and “Person-centered Health Care”? What Do They Mean and What Can They Do?
Peter Szatmari, MD, MSc, Cundill Center for Child and Youth Depression, Center for Addiction and Mental Health, Precision Menthal Health: Ready or Not?
Michael Milham, MD, PhD, Child Mind Institute, Can Individualized Profiles from Neuroimaging Inform Prediction?
Lisa Goldstein, PhD, Harvard Medical School, Massachusettes General Hospital, Sex Differences, Sensitive Periods and Risk for Psychopathology Across the Lifespan
Neil Risch, PhD, University of California San Francisco, Bahavior Genetics: A Two Way Street
Nora Volkow, PhD, NIAAA, NIDA, Discussant

1:30 PM – 1:45 PM   Break

3:45 PM – 4:00 PM   Break

4:00 PM – 4:30 PM   Awards

4:30 PM – 6:00 PM  SESSION 7: Personal Stories
Marylou Selo, Equilibrium, US Depression and Bipolar Support Alliance and the Mood Disorder Support Group of New York, Bipolar Lived and Examplified
Adina Taubman, MA, The Road Back–One Woman’s Journey from Depression to Recovery (Solo Performance and Q&A)
Dost Ongur, MD, PhD, Harvard Medical School, McLean Hospital, Discussant
Allan Young, PhD, King’s College London, Discussant

2021-2022 APPA Council


Kathleen Merikangas, PhD (National Institute of Mental Health)


Dost Öngür, MD, PhD (McLean Hospital)

Vice President

Roberto Lewis-Fernandez, MD (Columbia/NYS Psychiatric Institute)


William S. Stone, PhD (Harvard Medical School)


John de Figueiredo, MD (Yale School of Medicine)

Membership Chair

Helen Wilson, PhD (Stanford University)



James Potash, MD, MPH (Johns Hopkins School of Medicine) (Past President)

Cristiane Duarte, PhD (Columbia University)

Susan L. Santangelo, ScD (Maine Medical Center Research Institute)

Nehal Vadhan, D.Phil (Feinstein Institutes for Medical Research)

Timing is Everything: Rhythms and Dynamics of Psychopathology Across the Life Span

The 2022 APPA Annual Meeting will examine the importance of timing in the classification, assessment, etiology, risk factors, manifestations, course, and consequences of psychopathology. The speakers and discussants will cover the full range of evidence from our growing understanding of the short-term dynamics and rhythms of biologic systems to broader patterns of both contextual and biologic influences on manifestations of psychopathology across the life span. These principles will be applied to evidence about mental disorders including affective disorders, psychosis, substance abuse, and other conditions as well as their underlying domains such as mood, anxiety, sleep, attention, behavior, etc. The concepts and research presented will include neural dynamics, critical periods, environmental and intrinsic drivers of within day, daily, weekly, and seasonal rhythms from basic and human studies, determinants of sex differences across life stages, life course patterns derived from developmental psychopathology, and aging research and the role of timing of social and environmental influences on health and mental health. These principles will then be applied to identify how such rhythms and dynamics may be incorporated into our conceptualization, classification, risk estimation, and treatment of mental disorders.

Kathleen R Merikangas Ph.D.*
Senior Investigator, National Institute of Mental Health

Dr. Merikangas’ role as President of the APPA is not fulfilled as part of her official duties at the National Institute of Mental Health.


Wednesday, March 2, 2022

12:00 PM – 6:30 PM   Pre-Meeting Training Workshop Program

Thursday, March 3, 2022

9:00 AM – 11:00 AM   SESSION 1: Rhythms: Circadian Systems and Health
Kathleen Merikangas, PhD, NIMH, Chair
Till Roenneberg, PhD. LMU Munich – The Power of Actimetry as a Disgnostic Tool in Circadian Medicine
Elizabeth Klerman, MD, PhD, Massachusetts General Hospital, Harvard Medical School – What Time is it? Determining Individual Circadian Rhythms
Phyllis Zee, MD, PhD, Feinberg School of Medicine, Northwestern University, Circadian Rhythms and Sleep: Implications for Brain and Cardio-Metabolic Health